Alkaptonuria is known to be a rare disorder which is caused when the abnormal copy of genetic material is passed down from both the parents to the offspring. There is an HGD gene which is responsible for the formation of an enzyme, homogentisate 1,2-dioxygenase. This enzyme serves the role of catalyzing amino acids like tyrosine and phenylalanine.
If there occurs a mutation in this gene, then the body starts accumulating a substance which is known as homogentisic acid in the tissues as well as in blood. When this acid gets oxidized, it gives rise to alkapton which is excreted out through the urine, which is unusually darker in color. This accumulated substance leads to various other conditions like osteoarthritis, kidney stones etc.
Meiotic nondisjunction is much more likely than mitotic nondisjunction. Based on
A woman who is heterozygous, Bb, has brown eyes;
Explain why familial breast cancer shows a dominant pattern of inheritance in
How is an F′ factor different from an F factor?
With regard to the timing of conjugation, explain why the recipient
The raw material for evolution is random mutation. Discuss whether or
Why is an antibody used in this experiment? From
Explain the type of speciation (allopatric, parapatric, or sympatric
In fruit flies, curved wings are recessive to straight wings,
A recessive allele in mice results in an unusally long neck.
