A corepressor is such a molecule that is responsible for suppressing the expression of genes. In the case of prokaryotic cells, these corepressors are small molecules. The nature of corepressors is the protein in the eukaryotes and they tend to control the gene expression by getting bound to the repressor molecules.
Hence, the process of transcription is regulated by various states of activation and inactivation. The corepressor binds to the repressor transcription factor and then the repressor gets bound to the operator sequence of the gene and the transcription process is blocked.
The examples of corepressor include NCoR and SMRT. NCoR is found in the processes like inflammation and in activation of macrophages whereas SMRT contributes to the development of cardiac muscles.
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