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Aminotetralins are a class of compounds currently being studied for their promise as antidepressant drugs. The following conversion was employed during a mechanistic study associated with a synthetic...
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Steroidal derivatives are important pharmacologically and biologically, and they continue to be a popular backbone in the search for new biologically active steroid hormone analogues. Propose a possib...
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Allylic bromide 2 was recently used as a key fragment in progress toward the total synthesis of an analogue of amphidinolide N, a potent cytotoxic agent isolated from the marine organism Amphidinium s...
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Compound 3 (below) was used as an intermediate in a recently reported synthesis of the γ-secretase inhibitor BMS-708163. Compound 3 was made from compound 1 via the two-step process shown....
See AnswerQ: The m- and p-substituted methyl benzoates listed in the
The m- and p-substituted methyl benzoates listed in the table below were treated with NaOH in dioxane and water. The rate constants of saponification, k, are also listed in the table. Provide structur...
See AnswerQ: The plant Thapsia villosa is so poisonous that it is known as
The plant Thapsia villosa is so poisonous that it is known as the deadly carrot! Despite the toxicity of this herb, its historical use in traditional medicine makes its extracted compounds attractive...
See AnswerQ: Scorzocreticin (S)-1 was isolated from a plant that is
Scorzocreticin (S)-1 was isolated from a plant that is used for cooking traditional meat dishes on the Greek island of Crete. As part of a recent synthesis of scorzocreticin (S)-1, compound 1 was conv...
See AnswerQ: 46. Which monomer can be used to prepare the following polymer
46. Which monomer can be used to prepare the following polymer under acidic conditions? 47. Which monomers are formed when the following polymer undergoes acid-catalyzed hydrolysis? 48. Which polym...
See AnswerQ: (−)-Spongidepsin is a marine natural product that is toxic to some
(−)-Spongidepsin is a marine natural product that is toxic to some cancer cells. During a synthesis of (−)-spongidepsin, compound 1 was converted into compound 2. P...
See AnswerQ: Prostaglandins (Section 26.7) are a group of structurally
Prostaglandins (Section 26.7) are a group of structurally related compounds that function as biochemical regulators and exhibit a wide array of activity, including the regulation of blood pressure, bl...
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