Questions from Organic Chemistry

Q: Disorazoles are a family of structurally related natural products first isolated in

Disorazoles are a family of structurally related natural products first isolated in 1994 from the fermentation broth of the bacterium Sorangium cellulosum. These natural products exhibit anticancer pr...

Q: During a recent total synthesis of asteriscanolide, a sesquiterpene lactone with

During a recent total synthesis of asteriscanolide, a sesquiterpene lactone with unprecedented molecular architecture, compound A was heated with the Grubbs 2nd generation catalyst under an atmosphere...

Q: (−)-Rapamycin, a powerful immunosuppressive and antibiotic agent, is produced

(−)-Rapamycin, a powerful immunosuppressive and antibiotic agent, is produced by the bacterium Streptomyces hygroscopicus, found in the soil native to Easter Island (in the South Pac...

Q: The bicyclic compound cis-sabinene hydrate is a natural product that

The bicyclic compound cis-sabinene hydrate is a natural product that is one of the main molecules responsible for the flavor of the herb marjoram. It can be prepared as a racemic mixture via the one-p...

Q: Compound 1, called 5-epi-hydroxycornexistin, is a

Compound 1, called 5-epi-hydroxycornexistin, is a diastereoisomer of the herbicidal natural product hydroxycornexistin. The ninemembered carbocyclic core of compound 1 was recently synthesized using t...

Q: Compound 1 undergoes an intramolecular Simmons–Smith type reaction to afford

Compound 1 undergoes an intramolecular Simmons–Smith type reaction to afford a fused bicyclic meso product (compound 3), which can be used as a synthetic intermediate for subsequent...

Q: Propose a synthesis for the following transformation (be sure to count

Propose a synthesis for the following transformation (be sure to count the carbon atoms):

Q: Propose a plausible mechanism for the following transformation: /

Propose a plausible mechanism for the following transformation:

Q: Compound A is an amine that does not possess a chiral center

Compound A is an amine that does not possess a chiral center. Compound A was treated with excess methyl iodide and then heated in the presence of aqueous silver oxide to produce an alkene. The alkene...

Q: When D-glucose is treated with aqueous sodium hydroxide, a

When D-glucose is treated with aqueous sodium hydroxide, a complex mixture of carbohydrates is formed, including D-mannose and d-fructose. Over time, almost all aldohexoses will be present in the mixt...