Questions from Organic Chemistry

Q: Identify the N-terminal residue of a peptide that yields the

Identify the N-terminal residue of a peptide that yields the following PTH derivative upon Edman degradation:

Q: Treatment of a tripeptide with phenyl isothiocyanate yields compound A and a

Treatment of a tripeptide with phenyl isothiocyanate yields compound A and a dipeptide. Treatment of the dipeptide with phenyl isothiocyanate yields compound B and glycine. Identify the structure of t...

Q: Glucagon is a peptide hormone produced by the pancreas that, with

Glucagon is a peptide hormone produced by the pancreas that, with insulin, regulates blood glucose levels. Glucagon is comprised of 29 amino acid residues. Treatment with trypsin yields four fragments...

Q: When the N terminus of a peptide is acetylated, the peptide

When the N terminus of a peptide is acetylated, the peptide derivative that is formed is unreactive toward phenyl isothiocyanate. Explain.

Q: Predict the major product(s) of the reaction between L

Predict the major product(s) of the reaction between L-valine and: a. MeOH, H+ b. Di-tert-butyl-dicarbonate c. NaOH, H2O d. HCl

Q: Draw the structure of the product with the molecular formula C10H10O that

Draw the structure of the product with the molecular formula C10H10O that is obtained when the compound below is heated with aqueous acid.

Q: Show all steps necessary to make the dipeptide Phe-Ala from

Show all steps necessary to make the dipeptide Phe-Ala from L-phenylalanine and L-alanine.

Q: Draw all four possible dipeptides that are obtained when a mixture of

Draw all four possible dipeptides that are obtained when a mixture of L-phenylalanine and L-alanine is treated with DCC.

Q: Identify the steps you would use to combine Val-Leu and

Identify the steps you would use to combine Val-Leu and Phe-Ile to form the tetrapeptide Phe- Ile-Val-Leu.

Q: Identify all of the steps necessary to prepare the tripeptide Leu-

Identify all of the steps necessary to prepare the tripeptide Leu-Val-Ala with a Merrifield synthesis.