Definition of Feedback Loop

The feedback loop is a mechanism in which the gene that is responsible for encoding a certain transcription factor is being regulated by the same transcription factor. The transcription-translation feedback loop is an example of a negative feedback loop in which the genes are regulated by the proteins they themselves have formed. This mechanism of TTFL involves two important elements i.e. regulatory elements and protein products.


The positive regulatory elements serve the purpose of promoting the transcription process whereas this transcription is suppressed by the protein products formed during the mechanism. TTFL is a closed-loop means that it has to return to its fixed point even though if it gets disturbed.


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