Definition of Fragmentation

Fragmentation in mass spectrometry is a chemical dissociation that takes place when the electrons are removed from a molecule during the process of ionization. This ionization is brought about by the removal of the electrons from either a σ or a π-bond.


The process of breakage could be hemolytic or heterolysis. The energized molecular ions which are formed in the ionization chamber of the spectrometer are unstable. Such ions can create unique patterns in the mass spectrum. These fragments lead us to determine the molecular weight of the unknown molecule, as well as the structural information, is collected.

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