Definition of Kinetochore

The kinetochore is a cluster of protein molecules that are attached to the centromere of the chromosome during the process of cell division i.e. mitosis and meiosis. The kinetochore helps in the attachment of the spindle fibers and helps in the movement of the chromosomes. The structure of kinetochore is composed of a narrow band of chromatin that is highly dense.


It has an inner kinetochore domain and a laminar outer kinetochore domain that is composed of molecules accountable for binding and transducing the signals. The heterochromatin links the two sister chromatids and is important for the cohesion and kinetochore regulation.

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