Definition of Lock And Key Model



The enzymes bind to the substrate through the active site which is highly specific in nature. When the substrate combines with the enzyme, the distribution of the electrons presents in the substrate changes and it leads to the formation of products. The shape of the active site of the enzyme is complementary to that of the substrate molecules.

 


One of the models that explain the structure of an active site is the lock and key model which was explained by Emil Fischer in 1894. This states that the active site is a rigid structure and only that substrate that has conformity with it, would bind to it and form product.

 

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