All Related Questions of Alkylation

Q: Preparation of 2,2-dimethyl-3-octyne cannot

Preparation of 2,2-dimethyl-3-octyne cannot be achieved via alkylation of acetylene. Explain.

Q: Melphalan is a chemotherapy drug used in the treatment of multiple myeloma

Melphalan is a chemotherapy drug used in the treatment of multiple myeloma and ovarian cancer. Melphalan is an alkylating agent belonging to the nitrogen mustard family. Draw a likely mechanism for th...

Q: The following transformation cannot be accomplished by direct alkylation of an enolate

The following transformation cannot be accomplished by direct alkylation of an enolate. Explain why not and then devise an alternate synthesis for this transformation.

Q: We have seen that the alpha carbon atom of an enamine can

We have seen that the alpha carbon atom of an enamine can function as a nucleophile in a Michael reaction, and in fact, enamines can function as nucleophiles in a wide variety of reactions. For exampl...

Q: A Friedel–Crafts alkylation is an electrophilic aromatic substitution in which

A Friedel–Crafts alkylation is an electrophilic aromatic substitution in which the electrophile (E+) is a carbocation. In previous chapters, we have seen other methods of forming car...

Q: Identify whether each of the following compounds can be made using a

Identify whether each of the following compounds can be made using a direct Friedel–Crafts alkylation or whether it is necessary to perform an acylation followed by a Clemmensen redu...

Q: The following compound cannot be made with either a Friedel–Crafts

The following compound cannot be made with either a Friedel–Crafts alkylation or acylation. Explain.

Q: In the previous section, we learned how to use diethyl malonate

In the previous section, we learned how to use diethyl malonate as a starting material in the preparation of substituted carboxylic acids (the malonic ester synthesis). That method employed a step in...

Q: Nitriles undergo alkylation at the α position much like ketones undergo alkylation

Nitriles undergo alkylation at the α position much like ketones undergo alkylation at the α position. The α position of the nitrile is first deprotonated to...