Alkylation is a chemical reaction in which there is a transfer of an alkyl group from one chemical species to the other. Alkyls are known to be the derivatives of saturated hydrocarbons i.e. alkanes. The general formula of the alkyl is CnH2n+1. The alkyl group R can be shifted from one species to the other in the form of an alkyl carbocation, a free radical, or a carbanion.
Alkylating agents are chemical compounds that are responsible for the addition of an alkyl group in whatever starting material. On contrary, the compounds that help in the removal of these alkyl groups are termed as dealkylating agents which may have nucleophilic or electrophilic character.
Preparation of 2,2-dimethyl-3-octyne cannot
Melphalan is a chemotherapy drug used in the treatment of multiple myeloma
The following transformation cannot be accomplished by direct alkylation of an enolate
We have seen that the alpha carbon atom of an enamine can
A Friedel–Crafts alkylation is an electrophilic aromatic substitution in which
Identify whether each of the following compounds can be made using a
The following compound cannot be made with either a Friedel–Crafts
In the previous section, we learned how to use diethyl malonate
Nitriles undergo alkylation at the α position much like ketones undergo alkylation
