Definition of Base Excision Repair



Base excision repair is one of the mechanisms that repair DNA. The DNA can undergo damage when it is exposed to certain chemicals, radiations and mutagens. This phenomenon repairs the DNA throughout the cell cycle. The primary responsibility of the BER is to remove the small and distorted non-helical base lesions from the DNA.

 


These damaged bases may prove detrimental as they cause mutations by either wrong pairing or by forming breaks in the DNA during the process of replication. The enzyme that initiates the BER is DNA glycosylases and it serves the purpose of identifying and removing the damaged and wrong bases.

 

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