Definition of Biotransformation



Biotransformation is a biological process that involves the conversion of drugs into new chemical entities. This conversion of drugs is done by the action of certain enzymes. The new chemical species formed are relatively less active compounds and hence it becomes easy for them to get eliminated from the body.

 


The body organs which are prominently involved in the process of metabolizing a drug are the kidneys and gastrointestinal tract. These organs have the ability to undergo oxidative, hydrolysis, and conjugation reactions. Consequently, if these organs get damaged or attain a disorder, then the metabolism of drugs is highly affected.


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