Definition of Deleterious Mutation



Deleterious mutations are those changes in the genetic material that leads to an increased susceptibility of the organisms to a specific disease. When this type of mutation is acquired, it is likely for an organism to develop the symptoms but this is not certain.

 


The deleterious mutation has other names too like a pathogenic variant, susceptibility gene mutation and predisposing mutation. Most of the mutations that occur in the population are either neutral or deleterious. The proportion of advantageous mutations is very low. The deleterious mutations lead to the decreased fitness of an organism.

 

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