A dominant-negative mutation is a type of mutation whose gene product affects the normal, wild-type gene product in a harmful and negative manner. This happens when the gene product still has the ability to interact with those elements that normally affect the wild-type product. The negative mutation blocks some of the functions of these elements too.
The mutation that has occurred in the transcription factor removes that domain from it which is responsible for the activation process, but it still has an activated DNA binding domain. This would result in reduced levels of gene activation as the gene product blocks the wild-type transcription factor.
Meiotic nondisjunction is much more likely than mitotic nondisjunction. Based on
A woman who is heterozygous, Bb, has brown eyes;
Explain why familial breast cancer shows a dominant pattern of inheritance in
How is an F′ factor different from an F factor?
With regard to the timing of conjugation, explain why the recipient
The raw material for evolution is random mutation. Discuss whether or
Why is an antibody used in this experiment? From
Explain the type of speciation (allopatric, parapatric, or sympatric
In fruit flies, curved wings are recessive to straight wings,
A recessive allele in mice results in an unusally long neck.
