Haploinsufficiency is the phenomenon in which there is only one copy of a gene is present in a person that is potentially functional. This single functional copy of the gene is unable to give rise to a normal phenotype and hence haploinsufficiency shows the dominant pattern of inheritance.
The variant allele may have suffered from the loss of function mutation during inheritance or has arisen from a de novo mutation. This allele produces a very little or no product at all. On the contrary, the other allele produces the normal amount of product but the collective product is not enough to give the standard phenotype.
Meiotic nondisjunction is much more likely than mitotic nondisjunction. Based on
A woman who is heterozygous, Bb, has brown eyes;
Explain why familial breast cancer shows a dominant pattern of inheritance in
How is an F′ factor different from an F factor?
With regard to the timing of conjugation, explain why the recipient
The raw material for evolution is random mutation. Discuss whether or
Why is an antibody used in this experiment? From
Explain the type of speciation (allopatric, parapatric, or sympatric
In fruit flies, curved wings are recessive to straight wings,
A recessive allele in mice results in an unusally long neck.
