Definition of Histone Acyltransferase

Histone acyltransferase is an enzyme that plays its function by attaching the acetyl group to the -NH2 terminal tail that is present in a histone protein. The conserved amino acid i.e. lysine in the histone proteins are acylated by the transfer of acetyl group from acetyl-CoA. In this way, the lysine is converted into N-acetyllysine.


It has been observed that when the histone proteins are acylated, the gene expression is generally increased. It is also linked to the activation of the transcriptional process and is associated with euchromatin. These enzymes are able to acylate the non-histone proteins as well e.g. nuclear receptors and hence the gene expressed is increased.


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