Definition of Holoenzyme

Holoenzyme is a complex that is formed by an apoenzyme and a co-factor. Hence, it is such an enzyme which contains all the subunits along with a non-protein part that may be a metal ion, an organic compound etc. It is catalytically very active species. The co-factor attached to it is tightly bound to the enzyme molecule.


The other prosthetic groups i.e. iron, vitamins etc. that are organic in nature are covalently bonded with the enzyme. DNA and RNA polymerases are examples of holoenzymes. Both of them have complete machinery in order to perform their functions efficiently.


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