Definition of Homeodomain

Homeodomain is a domain of a protein that is encoded by the homeobox. Homeobox is a sequence of DNA which is composed of 180 base pairs and it is found in a particular gene that is known as a homeotic gene. The function of the homeotic gene is to govern and control the developmental fate of a certain part of a body.


The homeodomain is responsible for the binding of the protein to the major groove present in the structure of the DNA. It is found in the regulatory proteins present in the eukaryotic organisms. The structure of homeodomain is composed of three alpha-helices that are folded together in order to form a globular structure.


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