Definition of Homologous Recombination Repair

Homologous recombination repair is a phenomenon of repairing the breaks present in the double-stranded DNA molecule. It takes place when the DNA strand of the sister chromatid repairs a lesion present in the other sister chromatid. This is also known as homology-directed repair.


The homologous chromosome segment is utilized in exchanging the nucleotide sequences required to repair the damaged nitrogenous bases present in both the strands of DNA. This method is less prone to error and hence is more advantageous as compared to the other methods of DNA repair. This method is defined in three steps which are strand exchange, branch migration and resolution.


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