Definition of Integrase

Integrase is an enzyme which is responsible for incorporating the viral DNA or a retrotransposon in the chromosome. Hence, the viral DNA is spliced into the cellular chromosome with the aid of integrase. The two ends of the viral DNA are occupied by the four identical copies of integrase. This results in the formation of a stable complex that is known as intasome.


This intasome is then bound to the cellular DNA and consequently joins the viral DNA to the cellular DNA. The retrovirus integrase is formed by the retrovirus and performs its function of forming a covalent bond between the DNA of the virus and the host.

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