Loss of heterozygosity is the phenomenon in which the single functional allele gets inactivated when a genetic change has taken place in a heterozygous somatic cell. The loss of heterozygosity happens when a copy of one parent is lost in a region. The single-copy can never be heterozygous and in this way, the region of interest shows the loss of heterozygosity which is also known as hemizygosity.
It is commonly seen in the development of cancers as the copy of the functional tumor suppressor gene is absent. The other copy may also get silenced due to mutation and consequently, there is no tumor suppressor gene present which can protect the body and the body undergoes the state of cancerogenesis.
Meiotic nondisjunction is much more likely than mitotic nondisjunction. Based on
A woman who is heterozygous, Bb, has brown eyes;
Explain why familial breast cancer shows a dominant pattern of inheritance in
How is an F′ factor different from an F factor?
With regard to the timing of conjugation, explain why the recipient
The raw material for evolution is random mutation. Discuss whether or
Why is an antibody used in this experiment? From
Explain the type of speciation (allopatric, parapatric, or sympatric
In fruit flies, curved wings are recessive to straight wings,
A recessive allele in mice results in an unusally long neck.
