Definition of Mitotic Nondisjunction

Mitotic nondisjunction is an abnormality that occurs during the process of mitosis in which the two chromatids of a pair of a chromosome are unable to get separated under normal circumstances. In this way, both chromosomes remain attached to each other and transfer to only one daughter cell while the other daughter cell receives no chromosome.


This nondisjunction takes place during the anaphase of mitosis in which the chromatids separate and migrate to the opposite poles when the conditions are normal. This mitotic nondisjunction happens when some enzymes like topoisomerase II, condensing, and separase are unable to activate. This contributes to the formation of some kinds of cancers.  

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