Definition of R Factor



The R factor or RTF is the shortened form of Resistance Transfer Factor and it is an old name for the plasmid that is responsible for antibiotic resistance. It was first isolated from a bacterium known as Shigella by a group of Japanese scientists in 1959.

 


A single R-factor typically codes for many antibiotic resistance factors. These R-factors can be passed from one bacterial cell to the other by the phenomenon of conjugation. This is the most common mean by which resistance to antibiotics is spread between various species.

 

 


Example of R-Factor:

There is a plasmid known as RP1 which is responsible for encoding resistance against various antibiotics like ampicillin, kanamycin, and tetracycline. This factor was first identified in Pseudomonas but can also be maintained in E. coli.

 

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