Questions from Genetics


Q: What is a nucleosome-free region? Where are such regions

What is a nucleosome-free region? Where are such regions typically found in a genome? How are nucleosome-free regions thought to be functionally important?

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Q: Histones are thought to be displaced as RNA polymerase is transcribing a

Histones are thought to be displaced as RNA polymerase is transcribing a gene. What would be the potentially harmful consequences if histones were not put back onto a gene after RNA polymerase had pas...

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Q: What is an insulator? Describe two different ways that insulators may

What is an insulator? Describe two different ways that insulators may exert their effects.

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Q: What is DNA methylation? When we say that DNA methylation is

What is DNA methylation? When we say that DNA methylation is heritable, what do we mean? How is it passed from a mother to a daughter cell?

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Q: Let’s suppose that a vertebrate organism carries a mutation that causes some

Let’s suppose that a vertebrate organism carries a mutation that causes some cells that normally differentiate into nerve cells to differentiate into muscle cells. A molecular analysis reveals that th...

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Q: What is a CpG island? Where would you expect one to

What is a CpG island? Where would you expect one to be located? How does the methylation of CpG islands affect gene expression?

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Q: Describe how the binding of iron regulatory protein to an IRE affects

Describe how the binding of iron regulatory protein to an IRE affects the mRNAs for ferritin and the transferrin receptor. How does iron (Fe3+) influence this process?

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Q: What is meant by the term RNA world? Describe observations and

What is meant by the term RNA world? Describe observations and evidence that support this hypothesized period of life on Earth. From the perspective of living cells, what are the advantages of having...

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Q: Describe two different ways that histone modifications may alter chromatin structure.

Describe two different ways that histone modifications may alter chromatin structure.

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Q: Explain how HOTAIR plays a role in the transcriptional regulation of particular

Explain how HOTAIR plays a role in the transcriptional regulation of particular genes. 

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