Questions from Genetics

Q: Explain how DNA methylation and the formation of a DNA loop control

Explain how DNA methylation and the formation of a DNA loop control the expression of the Igf2 gene in mammals. How is this gene imprinted so that only the paternal copy is expressed in offspring?

Q: Let’s suppose a mutation removes the ICR next to the Igf2 gene

Let’s suppose a mutation removes the ICR next to the Igf2 gene. If this mutation is inherited from the mother, will the Igf2 gene (from the mother) be silenced or expressed? Explain.

Q: Outline the molecular steps in the process of X-chromosome inactivation

Outline the molecular steps in the process of X-chromosome inactivation (XCI). Which step plays a key role in choosing which of the X chromosomes will remain active and which will be inactivated?

Q: Following X-chromosome inactivation, most of the genes on the

Following X-chromosome inactivation, most of the genes on the inactivated X chromosome are silenced. Explain how. Name one gene that is not silenced.

Q: In general, explain how epigenetic modifications are an important mechanism for

In general, explain how epigenetic modifications are an important mechanism for developmental changes that lead to specialized body parts and cell types. How do the trithorax and polycomb group comple...

Q: List and briefly describe four types of molecules that can bind to

List and briefly describe four types of molecules that can bind to an ncRNA.

Q: Which component of the CRISPR-Cas system directly recognizes the bacteriophage

Which component of the CRISPR-Cas system directly recognizes the bacteriophage DNA?

Q: Look at Figure 17.6 and predict what would happen if

Look at Figure 17.6 and predict what would happen if the SRP RNA was unable to stimulate the GTPase activities of the GTPbinding proteins within SRP and the SRP receptor. From Figure 17.6:

Q: Compare and contrast the roles of crRNA and tracrRNA in the defense

Compare and contrast the roles of crRNA and tracrRNA in the defense process against bacteriophages provided by the CRISPRCas system.

Q: In the CRISPR-Cas system, does the tracrRNA act as

In the CRISPR-Cas system, does the tracrRNA act as a scaffold, guide, ribozyme, blocker, decoy, and/or alterer of protein function or stability?